Blair and Serena's Best Friendship Moments on Gossip Girl

Serena and Blair may have had their issues, but when bad times hit they were there for each other. In the Thanksgiving episode “Blair Waldorf Must Pie,” Blair and her mother, Eleanor (Margaret Colin), un-invite a bunch of people to Thanksgiving dinner—and Blair is devastated when her estranged father, Harold (John Shea), doesn’t make the cut. After spending the meal alone with her icy mom, Blair relapses into bulimic behavior and binges on pie made from her father’s secret recipe. She calls the formerly uninvited Serena —who rushes to her aid. As with many of their friendship moments, there’s a dash of frenemy. But let’s focus on the fact that Serena was there for Blair in her time of need like a bestie should be, shall we?